Browsing by Subject "Image analysis"

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    Open Access
    A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images
    (Springer Berlin Heidelberg, 2018-06-25) Malherbe, Stephanus T; Dupont, Patrick; Kant, Ilse; Ahlers, Petri; Kriel, Magdalena; Loxton, André G; Chen, Ray Y; Via, Laura E; Thienemann, Friedrich; Wilkinson, Robert J; Barry, Clifton E; Griffith-Richards, Stephanie; Ellman, Annare; Ronacher, Katharina; Winter, Jill; Walzl, Gerhard; Warwick, James M
    Background There is a growing interest in the use of 18F-FDG PET-CT to monitor tuberculosis (TB) treatment response. However, TB causes complex and widespread pathology, which is challenging to segment and quantify in a reproducible manner. To address this, we developed a technique to standardise uptake (Z-score), segment and quantify tuberculous lung lesions on PET and CT concurrently, in order to track changes over time. We used open source tools and created a MATLAB script. The technique was optimised on a training set of five pulmonary tuberculosis (PTB) cases after standard TB therapy and 15 control patients with lesion-free lungs. Results We compared the proposed method to a fixed threshold (SUV > 1) and manual segmentation by two readers and piloted the technique successfully on scans of five control patients and five PTB cases (four cured and one failed treatment case), at diagnosis and after 1 and 6 months of treatment. There was a better correlation between the Z-score-based segmentation and manual segmentation than SUV > 1 and manual segmentation in terms of overall spatial overlap (measured in Dice similarity coefficient) and specificity (1 minus false positive volume fraction). However, SUV > 1 segmentation appeared more sensitive. Both the Z-score and SUV > 1 showed very low variability when measuring change over time. In addition, total glycolytic activity, calculated using segmentation by Z-score and lesion-to-background ratio, correlated well with traditional total glycolytic activity calculations. The technique quantified various PET and CT parameters, including the total glycolytic activity index, metabolic lesion volume, lesion volumes at different CT densities and combined PET and CT parameters. The quantified metrics showed a marked decrease in the cured cases, with changes already apparent at month one, but remained largely unchanged in the failed treatment case. Conclusions Our technique is promising to segment and quantify the lung scans of pulmonary tuberculosis patients in a semi-automatic manner, appropriate for measuring treatment response. Further validation is required in larger cohorts.
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    Open Access
    Analysing the road reserve encroachment in Maseru Lesotho using remote sensing and image analysis
    (2021) Ralitsoele, Teboho; Sithole, George
    The increasing rate of urbanization and the problem of road reserve encroachment mean that there is no space for road expansion and sometimes for maintenance and road furniture, these and other problems have exposed the problem of road reserve encroachment. The main aim of this study was to investigate methods of finding the road reserve encroachment in Maseru Lesotho using aerial photos. The study used single image analysis and multiple image analysis methods. In single image analysis, the study used three methods of image classifications to find objects that are in the road reserve. Under classification, the study used both supervised and unsupervised image classifications. For supervised classification, the study used the direct image classification method where the aim was to look for every object found in the road reserve. For the indirect approach, the study looked for the ground to find objects in the road reserve. For unsupervised image classification, the study assumed that small clusters are encroachment. In multiple images analysis, the study used the 2015 and 2017 images to determine permanent objects found to have encroached road reserves. Here the assumption was that encroachment does not change over time, which means that unchanged objects during the change detection have encroached on the road reserve. The confusion matrix was used to tell the best performing method and the results show that the indirect method, both in Qoaling and Maqalika performed best. All the methods showed that there was an encroachment on a road reserve, and found that permanent objects were; houses, shops, and shopping centers. The study recommended the use of images with higher resolution and more bands, also that images be taken frequently.